Tratamiento con glucocorticoides en pacientes con inflamación relacionada a angiopatía amiloide cerebral: ¿qué tan útil son?
DOI:
https://doi.org/10.35839/repis.6.4.1553Palavras-chave:
corticoesteroides, inflamación, angiopatía amiloide cerebral, demencia vascular, enfermedad de alzheimerResumo
Objetivo. El objetivo de esta revisión consiste en analizar la evidencia más reciente sobre la utilidad de los glucocorticoides en pacientes con Inflamación relacionada a Angiopatía Amiloide Cerebral (IrAAC). Métodos. Revisión sistemática. Se llevó a cabo una búsqueda bibliográfica en los motores de búsqueda y bases de datos bases de datos PubMed, ScienceDirect, Embase, EBSCO y MEDLINE, incluyendo cualquier artículo relacionado con la evaluación de la utilidad, eficacia o seguridad de los glucocorticoides sobre la inflamación de angiopatía amiloide cerebral, sería incluido, dando prioridad a los estudios originales y a las revisiones sistemáticas y meta-análisis. Resultados. Se encontró que, la evidencia actual sobre su uso es limitada, derivando principalmente de casos reporte, series de casos y estudios retrospectivos. No obstante, parece ser que estos agentes ocasionan una respuesta favorable con solución parcial de las manifestaciones neurológicas de manera inmediata y/o progresiva a mediano y largo plazo, así como de los cambios anormales imagenológicos, dados por edema vasogénico y microsangrados corticales y subcorticales, aunque la mejoría de este último, no es muy marcado. Conclusión. La evidencia actual sobre el uso de glucocorticoides y su impacto sobre desenlaces clínicos y neuroimagenológicos es limitada.
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Copyright (c) 2022 Yelson A. Picón-Jaimes, Valentina Mendoza-Gallego, Ernesto Jaramillo-Valenzuela, Angie L. Monroy-Martínez, Andrés D. Ortega-Ovalle, Freddy E. Navarro-Bautista, Andrea P. Contreras-Castillo, Hernando J. Marín-Calderón
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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