Chronic myeloid leukemia in a pediatric patient: a clinicopathologic case

Authors

DOI:

https://doi.org/10.35839/repis.6.4.1576

Keywords:

Pathology, blood, leukemia, laboratories, microscopy

Abstract

Chronic myeloid leukemia (CML) is a common myeloproliferative disease in adults, characterized by an overproduction of granulocytes in bone marrow as a consequence of the t(9:22)(q34;q11) translocation, known as Philadelphia chromosome. We present a case of CML in a 12-year-old male patient, who was admitted for outpatient care at the Alberto Sabogal Sologuren National Hospital. The clinical and laboratory findings of the case are described. Also, a general presentation of the disease is made and the differences between adult and pediatric CML are discussed, since it is a rare neoplasm in pediatric patients.

Downloads

Download data is not yet available.

References

Spivak JL. Myeloproliferative Neoplasms. The New England Journal of Medicine. 2017;376:2168-81. DOI: 10.1056/NEJMra1406186

Hurtado Monrroy R, Vargas Viveros P, Cortes Franco J. Chronic Myeloid Leukemia Current Concepts in Physiopathology and Treatment. [Internet] 2007. 2007;2(3):137-47. [Citado el 01 de setiembre de 2022] En: http://incan-mexico.org/revistainvestiga/elementos/documentosPortada/1193427453.pdf

Forda M, Mauro M, Aftandilian C, Sakamoto kathleen, Hijiya N. Management of Chronic Myeloid Leukemia in Children and Young Adults. 2022. 2022;121-6. DOI: 10.1007/s11899-022-00673-5

Hijiya N, Schultz K, Metzler M, Milton F, Suttorp M. Pediatric chronic myeloid leukemia is a unique disease that requires a different approach. 2016. 2015;127(4):392-9. DOI: 10.1182/blood-2015-06-648667.

Hijiya N, Suttorp M. How I treat chronic myeloid leukemia in children and adolescents. 2019. 2018;33(22):2374-84. DOI: 10.1182/blood.2018882233.

Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring. 2020. 95(6):691-709. DOI: 10.1002/ajh.25792

Mishra M, Odyuo B, Webster J. Immature granulocyte percentage in early chronic myeloid leukemia. 2022. 2021;12(4):217-9. DOI: 10.4103/joah.joah_4_21

Ningombam A, Acharya S, Sarkar A, Kumar K, Chopra A. Scattergram patterns of hematological malignancies on sysmex XN-series analyzer. 2021. 2021;12(2):83-9. DOI: 10.4103/joah.joah_176_20

Gupta M, Chauhan K, Singhvi T, Kumari M. Useful information provided by graphic displays of automated cell counter in hematological malignancies. 2018. 2017;32:1-8. DOI: 10.1002/jcla.22392

Published

2022-10-30

Issue

Section

Casos clínicos

How to Cite

1.
Chronic myeloid leukemia in a pediatric patient: a clinicopathologic case. Rev Peru Investig Salud [Internet]. 2022 Oct. 30 [cited 2025 Oct. 10];6(4):225-9. Available from: http://revistas.unheval.edu.pe/index.php/repis/article/view/1576

Similar Articles

1-10 of 25

You may also start an advanced similarity search for this article.