Nitrofurantoin susceptibility profile versus other antibiotics tested in uropathogens- a retrospective study from India

Anuja Gupta; Bhawna Sharma

doi:10.54034/mic.e2084

Authors

Anuja Gupta Assistant Professor, Department of Microbiology, VMMC &Safdarjung Hospital. New Delhi-110029, India https://orcid.org/0000-0001-9597-6185
Bhawna Sharma Associate Professor, Department of Microbiology, VMMC &Safdarjung Hospital. New Delhi-110029, India https://orcid.org/0000-0003-1420-3573

DOI:

https://doi.org/10.54034/mic.e2084

Keywords:

nitrofurantoin, antimicrobial drug resistance, urinary tract infections

Abstract

Introduction. Urinary Tract Infection (UTI) is one of the most common bacterial infections encountered by clinicians worldwide. The emergence of multidrug-resistant uropathogens necessitates a review of their susceptibility profiles. This study aims to assess the susceptibility trends of uropathogens to a panel of drugs, with special emphasis on Nitrofurantoin (NFT). Methods. A retrospective analysis was conducted on 2,099 mid-stream clean catch urine samples processed by standard microbiological methods. Clinical and Laboratory Standards Institute (CLSI) guidelines (2019) were followed. Statistical analysis was performed. Results. Out of all samples, 212 were culture positive. Escherichia coli (34.9%) and Enterococcus spp. (15.1%) were the most common Gram-negative and Gram-positive organisms, respectively. Gram-negative isolates were most susceptible to Colistin (97.38%), followed by NFT (69.35%). Gram-positive uropathogens were most sensitive to Linezolid (100%), followed by Vancomycin and NFT, each with 92.45% susceptibility. Conclusion. The increase in antibiotic resistance among various uropathogens underscores the need for surveillance data to inform the appropriate selection of antibiotics. Our study highlights that, among the panel of antibiotics tested, NFT appears to be a viable alternative for treating multidrug-resistant uropathogens.

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References

Sule H, Uba A, Kumurya AS. Antibiotic susceptibility pattern of uropathogens from some selected hospitals in Kano-Nigeria. J MicrobiolExp 2018; 6(2), 127-134. doi: 10.15406/jmen.2018.06.00202.

Santosh, K, Siddiqui, S. Prevalence and Antibiogram of Uropathogens from Patients Attending Tertiary Care Hospital: An overview. Int J Med Microbiol Trop Dis 2017; 3(1), 20-23.

Goyal A, Kaur K. Assessment of Drug Sensitivity of Different Urinary Isolates to Nitrofurantoin and its Comparison with Other Drugs-A Retrospective Study. J ClinDiagn Res. 2022 Apr, Vol-16(4): DC06-DC08. DOI: 10.7860/JCDR/2022/51845.16243

Seifu WD, Gebissa AD. Prevalence and antibiotic susceptibility of Uropathogens from cases of urinary tract infections (UTI) in Shashemene referral hospital, Ethiopia. BMC Infect Dis 2018; 30. doi: 10.1186/s12879-017-2911-x.

Adugna B, Sharew B, Jemal M.Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Factors of Community- and Hospital-Acquired Urinary Tract Infection at Dessie Referral Hospital, Dessie, Northeast Ethiopia. Int J Microbiol(2021); 5553356, 1-14. doi: 10.1155/2021/5553356.

Mukherjee S, Mishra S, Tiwari S. Aetiological profile and antibiogram of urinary isolates causing UTI in patients attending a tertiary care hospital of Western Odisha. J Evolution Med Dent Sci 2020; 9(09), 662-667. doi: 10.14260/jemds/2020/144.

Gupta A, Sharma B. Recent trends in uropathogenic infections in patients of a tertiary care center, New Delhi, India, –a topic of urgent attention. MIR J 2023; 10(1), 39-44. doi: 10.18527/2500-2236-2022-10-1-39-44

K. S. HK, A. AP, Theckel PG, Divakaran B, Sathar S, R. A, S. RV. Prevalence of multidrug resistant uropathogens isolated from different age groups in South-India: a cross-sectional study. Int J Res Med Sci [Internet]. 2022 Mar. 28 [cited 2024 Apr. 6]; 10(4):905-12

Hussain A, Ewers C, Nandanwar N, et al. Multiresistanturopathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage. Antimicrob Agents Chemother. 2012; 56(12): 6358-6365. doi: 10.1128/AAC.01099-12.

Bhargava K, Nath G, Bhargava A, Kumari R, Aseri GK and Jain N (2022) Bacterial profile and antibiotic susceptibility pattern of uropathogens causing urinary tract infection in the eastern part of Northern India.Front. Microbiol. 13:965053. doi: 10.3389/fmicb.2022.965053.

Gautam G, Gogoi S, Saxena S, Kaur R, Dhakad MS. Nitrofurantoin Susceptibility Pattern in Gram-Negative Urinary Isolates: In Need of Increased Vigilance. J Lab Physicians. 2021 Sep;13(3):252-256. doi: 10.1055/s-0041-1731106.

Neelima A, Kiranmai. Nitrofurantoin susceptibility of ESBL grm negative isolates from patients with urinary tract infection (UTI) in a rural teaching hospital of Telangana. Trop J Path Micro 2016; 2(3): 159-163. DOI: 10.17511/JOPM.2016.I03.13

Meena S, Mohapatra S, Sood S, Dhawan B, Das BK, Kapil A. Revisiting Nitrofurantoin for Vancomycin Resistant Enterococci. J ClinDiagn Res. 2017; 11(6): DC19-DC22. doi:10.7860/JCDR/2017/25140.10140.

Squadrito FJ, del Portal D. Nitrofurantoin. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470526/

Procop, G. W. Koneman'scolor atlas and textbook of diagnostic microbiology.7th Edition. Philadelphia: U.S.A. Wolters Kluwer Health; 2017.

Tille, P.M. Bailey & Scott's diagnostic microbiology. 14th Edition. Missouri: U.S.A. Elsevier; 2017.

Wayne, P. CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 29thEdition. CLSI supplement M100. Clinical and Laboratory Standards Institute; 2019.

Coyle, M.B. Manual of Antimicrobial Susceptibility Testing. American Society for Microbiology; 2005.

Akhter S, Rizwan A. S. M.Antibiotic Resistance Pattern of Common Uropathogens among Adult Inpatients of a Tertiary Teaching Hospital. J Adv Med Medical Res (2021);33(4), 59-65. doi:10.9734/jammr/2021/v33i430834.

Naik T B, Lavanya J, Upadhya A, Mane V. Gram positive uropathogens and their antibiogram: Data analysis at a tertiary care hospital in Karnataka. Indian J Microbiol Res 2018; 5(1), 71-75. doi: 10.18231/2394-5478.2018.0014.

Kasew D, Desalegn B, Aynalem M, Tila S, Diriba D, Afework B, et al. Antimicrobial resistance trend of bacterial uropathogens at the university of Gondar comprehensive specialized hospital, northwest Ethiopia: A 10 years retrospective study. PLoS ONE 2022;17(4). doi: 10.1371/journal.pone.0266878.

Nahar A, Hasnat S, Akhter H, Begum N. Evaluation of antimicrobial resistance pattern of uropathogens in a tertiary care hospital in Dhaka city, Bangladesh. SE Asia J. Pub. Health [Internet]. 2018 Nov. 28 [cited 2022 Nov. 24];7(2):12-8. doi: 10.3329/seajph.v7i2.38851.

Tesfa T, Baye Y, Sisay M, Amare F, Gashaw T. Bacterial uropathogens and susceptibility testing among patients diagnosed with urinary tract infections at HiwotFana Specialized University Hospital, Eastern Ethiopia. SAGE Open Med 2021; 16(9). doi: 10.1177/20503121211001162.

Derbie A, Hailu D, Mekonnen D, Abera B, Yitayew G. Antibiogram profile of uropathogens isolated at Bahir Dar Regional Health Research Laboratory Centre, Northwest Ethiopia. Pan Afr Med J 2017; 26,134. doi: 10.11604/pamj.2017.26.134.7827.