Granulomatous mesenteric lymphadenitis after three doses of the COVID-19 vaccine

Vitorino Modesto dos Santos; Lister A. Modesto dos Santos; Laura Campos-Modesto; Julia Campos-Modesto

doi:10.54034/mic.e1725

Authors

Vitorino Modesto dos Santos Armed Forces Hospital and Catholic University, Brasília-DF, Brazil. and Catholic University, Brasília-DF, Brazil https://orcid.org/0000-0002-7033-6074
Lister A. Modesto dos Santos General Surgery of the IAMSPE, São Paulo-SP, Brazil
Laura Campos-Modesto University Center of Brasília-DF, Brazil https://orcid.org/0000-0002-9401-2277
Julia Campos-Modesto Catholic University of Brasília, Brazil

DOI:

https://doi.org/10.54034/mic.e1725

Keywords:

COVID-19, granulomatous reaction, mesenteric lymphadenitis, vaccine

Abstract

Lymphadenopathy related to vaccination has been reported as an adverse effect of mRNA-based COVID-19 vaccines. Most cases are regional lymph nodes near of injection site, with mild-moderate 18 F-fluorodeoxyglucose uptake on positron emission tomography. We report a middle-aged Brazilian man with mesenteric lymphadenitis manifested five days after the third dose of the Pfizer-BioNTech mRNA-based vaccine against COVID-19. The patient had no known risk factors and evolved with rapid clinical improvement. The imaging findings, laboratory determinations, histopathological and microbiological evaluations raised doubts about the hypothesis of an eventual adverse effect of the vaccine. The aim is to call attention to possible rare reactions of SARS-CoV-2 vaccinations.

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Author Biography

Lister A. Modesto dos Santos, General Surgery of the IAMSPE, São Paulo-SP, Brazil

Preceptor of General Surgery of the IAMSPE, São Paulo-SP, Brazil

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