Granulomatous mesenteric lymphadenitis after three doses of the COVID-19 vaccine


  • Vitorino Modesto dos Santos Armed Forces Hospital and Catholic University, Brasília-DF, Brazil. and Catholic University, Brasília-DF, Brazil
  • Lister A. Modesto dos Santos General Surgery of the IAMSPE, São Paulo-SP, Brazil
  • Laura Campos-Modesto University Center of Brasília-DF, Brazil
  • Julia Campos-Modesto Catholic University of Brasília, Brazil



COVID-19, granulomatous reaction, mesenteric lymphadenitis, vaccine


Lymphadenopathy related to vaccination has been reported as an adverse effect of mRNA-based COVID-19 vaccines. Most cases are regional lymph nodes near of injection site, with mild-moderate 18 F-fluorodeoxyglucose uptake on positron emission tomography. We report a middle-aged Brazilian man with mesenteric lymphadenitis manifested five days after the third dose of the Pfizer-BioNTech mRNA-based vaccine against COVID-19. The patient had no known risk factors and evolved with rapid clinical improvement. The imaging findings, laboratory determinations, histopathological and microbiological evaluations raised doubts about the hypothesis of an eventual adverse effect of the vaccine. The aim is to call attention to possible rare reactions of SARS-CoV-2 vaccinations.


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Author Biography

Lister A. Modesto dos Santos, General Surgery of the IAMSPE, São Paulo-SP, Brazil

Preceptor of General Surgery of the IAMSPE, São Paulo-SP, Brazil


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How to Cite

Modesto dos Santos, V., Modesto dos Santos, L. A., Campos-Modesto, L., & Campos-Modesto, J. (2023). Granulomatous mesenteric lymphadenitis after three doses of the COVID-19 vaccine. Microbes, Infection and Chemotherapy, 3, e1725.




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